NFE2L2 and Parkinson disease: Following is the summary of data with noticeable differences between control and PD tissues: First, NFE2L2 (encoding NRF2) showed increased expression in in PD SN and locus coeruleus-LC with a higher (albeit, statistically not significant) expression in the dorsal motor nucleus of vagus-DMX (Fig. 2A, GSE4349).