NFE2L2 and Parkinson disease: In order to assess the significance of pathological CNS aSyn accumulation in the context of the altered NRF2-dependent gene response observed in PD, we examined phospho-NRF2 (S40) immunostaining in conjunction with the assessment of NRF2-responsive gene expression in the brains of transgenic M83 mice (expressing the aggregation prone A53T mutant human aSyn) [36].