NFE2L2 and Parkinson disease: In this report we show that in PD midbrain harboring pathological LB lesions (SN and PAG), there is significant nuclear enrichment of phosphorylated NRF2 (S40), a post-translational modification putatively indicating augmented NRF2 dependent anti-oxidant response (Fig. 1D, 1F and Additional file 1: Fig. S1B).