NFE2L2 and Parkinson disease: In this report, we show increased nuclear localization of NRF2 in post-mortem PD midbrain in the presence of Lewy related aSyn pathology, as detected by immunonhistochemical (IHC) detection of phosphorylated NRF2 on the residue serine-40 (p-NRF2, S40), a robust post-translational modification associated with the nuclear accumulation of NRF2 [29–31].