In order to establish the role of pathological aSyn accumulation to altered NRF2 response, we performed IHC and gene expression analyses in a transgenic mouse model of synucleinopathy expressing the PD-associated mutant Ala53Thr (A53T) aSyn (the M83 line) [36, 37]. Here, NFE2L2 is linked to synucleinopathy.