The enriched pathways (eg, starch and sucrose metabolism and MAPK signaling pathway) and related genes (eg, IL1B and ENPP1) have been reported association with T2DM [22–24], which indicated that lnc-HIST1H2AG-6 and lnc-AIM1-3 might play a role in T2DM. This evidence concerns the gene ENPP1 and type 2 diabetes mellitus.