ICOSLG and melanoma: By querying The Cancer Genome Atlas (TCGA, N = 480) patient datasets of melanoma samples, we found that the CD40 expression was significantly correlated with CD80 (Spearman p < 0.0001, r = 0.6456) and ICOS-L (Spearman p < 0.0001, r = 0.5209) in tumors from melanoma patients (Fig. 7 a).