This meta-analysis study revealed the importance of both tumor-cell-intrinsic (e.g., tumor mutational burden and PD-L1 expression) and tumor-cell-extrinsic (e.g., CXCL9, CD8A, CXCL13, CCR5 and T cell inflamed gene expression signature) factors underpinning ICB sensitization. This evidence concerns the gene CD8A and neoplasm.