CD40 and hereditary clear cell renal cell carcinoma: Importantly, the induction of CD40 on cancer cells, but not normal cells, promotes apoptotic and/or necrotic signaling, which results in the cell death of renal cell carcinoma [29], urothelial cell carcinoma [30], ovarian carcinoma [31, 32], cervical carcinoma [33] and bladder carcinoma [34].