Notably, while melanoma cells bearing either NRASQ61R (SKMel2) or BRAFmut (HS294T, SkMel5, A375, YUMM 5.2, YUMM 2.1 and YUMM 3.3) were sensitive to low dose RGS treatment at 0.1 μM, the NRASWTBRAFWT B16F10 cells were not sensitive to 0.1 μM RGS, but were sensitive to 1 μM. This evidence concerns the gene PITX2 and melanoma.