The independent association between native T2 and hs-cTnT in patients with severe CKD (eGFR < 29 ml/min/1.73 m2) is a central new finding, reiterating the role of increased myocardial fluid, in addition to myocardial fibrosis, as an integral part of structural LV remodeling in CKD [30]. The gene discussed is TNNT2; the disease is Myocardial fibrosis.