In the future, more researches need to be conducted: (1) To confirm the regulatory axis of SNHG16/miR-128-3p/HMGB3 in larger number of female and male rats; (2) To evaluated the expressions of SNHG16/miR-128-3p/HMGB3 in ALI patients with sepsis. This evidence concerns the gene HMGB3 and Sepsis.