Treg‐secreted exosomes (Treg‐EXs) were found to markedly decrease the myocardial infarct size and suppress apoptosis of myocardial cells in mice with MI, which was along with a reduction in the M1 marker iNOS and an increase in Arg‐1 M2 marker as well as a reduction in the pro‐inflammatory mediators, such as IL‐1β and TNF‐α, and an increase in the anti‐inflammatory mediators, such as IL‐10 and TGF‐β.109. This evidence concerns the gene TGFB1 and myocardial infarction.