In the mouse heart, the pool of p16/Cdkn2a+ senescent cells also increases with age (Grosse et al., 2020; Torella et al., 2004) and their clearance reverts age‐related phenotypes in cardiovascular disorders and improves heart function in chronologically aged mice (Shimizu & Minamino, 2019; Walaszczyk et al., 2019; Zhu et al., 2015). Here, CDKN2A is linked to cardiovascular disorder.