Around the age of 8 months, both male and female KO mice had increased fasting glucose levels of around 180 mg/dl, and increased fasting serum insulin levels as compared with WT mice (Fig. 2c, d and Supplementary Fig. 2b), indicating that IRF3 KO mice progressively develop hyperglycemia and hyperinsulinemia. This evidence concerns the gene IRF3 and hyperinsulinism.