Despite the results of our study have not found significant differences in FM% using DEXA technique between subjects with IBD and HCs, it is known that patients with IBD are at increased risk of having altered body composition because of several risk factors including not only malnutrition secondly to the underlying gastrointestinal disease but also pharmacological treatment (corticosteroids, anti-TNFα therapy). The gene discussed is TNF; the disease is nutritional deficiency disease.