DYRK1A and autism spectrum disorder: It has to be pointed out, however, that owing to the partial tetraploidy of teleosts, zebrafish contains two paralogs named dyrk1aa and dyrk1ab. Nevertheless, Dyrk1A function is well conserved in zebrafish demonstrated by a loss of function mutation in dyrk1aa that was shown to result in social interaction impairment reminiscent of autism spectrum disorder (24).