DYRK1A and Anxiety: Although this reduced exploratory activity in a novel environment could be a secondary consequence of deficits in motor coordination, it is intriguing that this phenotype is complementary to adult zebrafish homozygous for a loss-of-function allele of dyrk1aa. These zebrafish with lack of Dyrk1A function in all its expression domains display an increased exploratory behavior, which has been interpreted as a sign of reduced anxiety (24).