IMiDs hijack the CRL4CRBN E3 ligase to ubiquitinate and degrade two essential lymphoid transcription factors, IKZF1 (Ikaros) and IKZF3 (Aiolos), which leads to the downregulation of IRF4 and MYC, resulting in the toxicity of MM cells [44, 45]. Here, IKZF1 is linked to Miyoshi myopathy.