In tumor entities derived from normally E-Cadherin positive cells types (Fig. 2b), at least a weak E-Cadherin positivity was preserved in 35 (45.5%) of 77 tumor entities in ≥99% of all interpretable examples and in 61 (79.2%) tumor entities in ≥90% of all analyzable cases. This evidence concerns the gene CDH1 and neoplasm.