The finding that most tumor types show either very high or very low E-Cadherin expression frequencies reflects the fact that frequent and intense E-Cadherin immunostaining is commonly seen in cancers derived from E-Cadherin positive normal cell types while neo-expression of E-Cadherin is rare and usually low in neoplasia derived from E-Cadherin negative normal cells. Here, CDH1 is linked to neoplasm.