Increased E-Cadherin expression was related to advanced tumor stage (p = 0.0424), reduced overall survival (p = 0.0243), higher risk of recurrence (p = 0.0410) and cancer specific survival (p = 0.0138) in papillary RCC, and to advanced tumor stage (p = 0.0276) and high Thoenes grade (p = 0.0035) – but not patient prognosis – in clear cell RCC (Table 2, Fig. 4). The gene discussed is CDH1; the disease is cancer.