Furthermore, the BV combined with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) regimen was also assessed as frontline therapy in a phase I/II multicenter trial (NCT01994850) using 6 cycles of treatment to assess toxicity and efficacy for 29 patients with CD30-positive B cell lymphomas, including 22 PMBCL, 5 DLBCL, and 2 GZL [68]. This evidence concerns the gene TNFRSF8 and B-cell non-Hodgkin lymphoma.