CHEK1 and cervical squamous intraepithelial neoplasia: In addition, we identified that CHEK1 activated NEK2 (data not shown), an established MM CIN marker reported in our previous study [26], while NEK2 stimulated CIN in cancer cells by regulating CEP250, a core centrosomal protein essential for centriole–centriole cohesion [42, 43].