The mesenchymal markers Matrix metalloproteinase-2 (MMP2), Vimentin, N-cadherin, Snail and Slug were significantly down-regulated, whereas the epithelial markers E-cadherin was notably upregulated by FOXH1 depletion in both lung cancer cell lines (Fig. 5a, b). This evidence concerns the gene SNAI2 and lung carcinoma.