For example, EZH2, a catalytic subunit of polycomb repressive complex 2 (PRC2) and one of the most reported methyltransferases which represses gene expression via methylation of lysine 27 of histone 3 (H3K27) [37, 38], requires the presence of CBX8 for its biological actions in driving germinal center formation and lymphoma precursor lesions [39]. The gene discussed is CBX8; the disease is lymphoma.