The TF motif enrichment analysis (based on motif predictions from JASPAR [20]) exhibited that around 50–60% of gained or lost peaks overlapped with ZNF263, SP1, and SP2, and other known co-factors of p53 (as mentioned above) in both breast and colon cancers (Fig. 2a-d, Additional file 1 Table S4), but their enrichment was not significant (q > 0.1) as compared to non-significant peaks. The gene discussed is SP2; the disease is malignant colon neoplasm.