Although the previous studies including the ChIP-seq of mutant p53 and gene expression-based analysis helped to identify genes (dys)regulated in the mutant p53 cell lines and tumours, the local chromatin changes induced by mutant p53 (either through direct DNA binding or by interacting with other TFs or chromatin-modifying enzymes) in primary tumours is poorly understood. The gene discussed is TP53; the disease is neoplasm.