RAP2A and familial pancreatic carcinoma: As shown in Fig. 4A a total of four online microarray datasets—Badea Pancreas, Grutzmann Pancreas, lacobuzio-Donahue Pancreas 2 and Pei Pancreas—were included in our study, which consistently indicated that RAP2A mRNA level was significantly overexpressed in pancreatic cancer tissues (gene median rank: 2351.0, p = 0.037).