IU1, an inhibitor of USP14, can increase UPS activities, promote Tau degradation, and enhance mitochondrial elimination in neuronal cells.14, 15, 16 Similarly, dysregulation of USP14 has been reported in several tumors, including breast cancer, lung adenocarcinoma, and epithelial ovarian cancer.17, 18, 19 However, whether USP14 is involved in preeclampsia remains elusive. Here, USP14 is linked to preeclampsia.