Nox1 overexpression reversed the effects of alarin on attenuated the increases of collagen I, collagen III and TGF-β levels the herat of MI rats; while, Nox1 overexpression elevated the expression levels of collagen I, collagen III and TGF-β in the heart of rats (Fig. 5C). The gene discussed is NOX1; the disease is myocardial infarction.