Moreover, a selective ERRγ agonist, DY131, inhibited growth of ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells (Yamamoto et al. 2012), suggesting a subtle harmonized interaction between ERα and ERRγ in the regulation of tumor cell proliferation, which is supported by our observation of a positive correlation between the expression of ERRγ and ERα. Here, ESRRG is linked to endometrial cancer.