SETD2 and neoplasm: These results are consistent with the negative role of SETD2 on these pathway39 and like SETD2, KDM4A has been suggested to be involved in DNA repair, transcription initiation, recombination and tumour growth in some models.14 Based on this, in the future it should be possible to generate KDM4A expression signature profiles and identify patients that are particularly dependent on these pathways.