IL10 and systemic lupus erythematosus: Furthermore, the VLPs were used to successfully deliver a BK polyomavirus (BKPyV) LT peptide-specific small hairpin RNA to inhibit BKPyV replication in human kidney cells20 and to deliver an interleukin (IL)-10 RNA interference vector into macrophage cells to reduce IL-10 expression21 as a possible gene therapy for systemic lupus erythematosus.