Notably, the incubation of exosomal miR-21-5p derived from CRC cells increased miR-21-5p expression in recipient HUVECs, subsequent suppressed KRIT1 and actived the β-catenin signaling pathway, consequently induced angiogenesis and vascular permeability in CRC (Fig. 6). This evidence concerns the gene KRIT1 and colorectal carcinoma.