IL6 and obesity due to melanocortin 4 receptor deficiency: In general, obesity is characterized by chronic inflammation and increased expression and release of proinflammatory neurohumoral factors, including adipokines such as leptin and adiponectin, and proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1 and IL-6 [4].