Moreover, in the PPI network, the top 13 targets, including BCL2L1, PTGS2, TP53, CASP3, CXCL8, EGFR, CSF2, MAPK14, TNF, VEGFA, MCL1, MAPK1, and IL1B, were selected as core targets that may play vital roles in emodin against COVID-19. The gene discussed is TP53; the disease is COVID-19.