The cellular phenotypes associated with G2019S, I2020T, and R1441C/Y1699C and other PD-associated mutations include perturbation of MT-related processes such as vesicular trafficking, autophagy, cilia formation, and nuclear/mitochondria morphology, so it is very likely that LRRK2 dysfunction physiologically interferes globally with dynamic cross-talk with MTs (9, 29, –31). This evidence concerns the gene LRRK2 and Parkinson disease.