This is consistent with prior data showing transfer of LCMV-specific CD4+ T cells to mice with CD8+ T cell exhaustion from chronic infection improved CD8+ T cell proliferation and function,46 47 and is the focus of an ongoing phase I trial (NCT03691376) evaluating whether NY-ESO-1 directed CD8 TCR responses can benefit from concomitant CD4 TCR mediated help in clearance of chemo resistant ovarian cancer. This evidence concerns the gene CD8A and ovarian carcinoma.