CD4 and neoplasm: Adoptive transfer of m1G4 CD8+ T cells into HHD mice followed by NY-ESO-1 vaccination demonstrated significant tumor clearance despite transfer of suboptimal cell doses (1×105 cells), and future work can build on this by modeling various amounts of CD4 T cell help and varying the NY-ESO-1-TCR affinity dynamics using our described altered peptide libraries.27