We also analyzed a screen more targeted to leukemia, involving two KMT2Ar cell lines, MOLM-13 (KMT2A-MLLT3 AML) and MV4-11 (KMT2A-AFF1 pediatric AML) and two non-leukemic cancer cell lines, HT-29 (colon adenocarcinoma) and HT-1080 (fibrosarcoma) (Tzelepis et al. 2016). The gene discussed is AFF1; the disease is colon adenocarcinoma.