Cluster 4 is specific to AML and ALL data sets with low activity across all FBM cell types (Supplemental Fig. S3D) and includes MAZ and PROM1. Cluster 5 is inactive in all of the data sets, and pathway enrichment implies this represents an immortalized cell program (e.g., cell junction organization) (Supplemental Fig. S3C). Here, PROM1 is linked to acute myeloid leukemia.