Residual tumor cells in each of these models were also enriched for phenotypes reported to be associated with TICs—EMT, in the case of HER2/neu, and a CD24+Thy1+ cell surface phenotype, in the case of Wnt1. Despite these suggestive phenotypic traits, functional studies revealed that residual tumor cells were not enriched for primary tumor TICs. Here, THY1 is linked to neoplasm.