Overall, despite the association between EMT, stem-like cells, and resistance to therapy reported in some experimental contexts, our findings that HER2/neu residual disease is enriched for cells with an EMT-like phenotype whereas Wnt1 residual disease is not, and that neither HER2/neu nor Wnt1 residual disease is enriched for primary tumor TICs, suggest that the properties of TICs, mammary stem cells, and EMT are separable, at least in some contexts. This evidence concerns the gene WNT1 and neoplasm.