Enrichment analysis performed for genes associated with breast cancer stem-like cells [76] revealed that residual tumor cells in both the HER2/neu and Wnt1 models upregulated genes associated with human breast cancer TICs (Fig. 4f, h; p value HER2/neu = 0.001; p value Wnt1 = 2.23E−12). This evidence concerns the gene WNT1 and breast cancer.