Additionally, correlation analysis by GEPIA showed that multiple key transcripts in the PI3K/AKT/mTOR signaling pathway, such as PIK3CA, PIK3CB, PIK3R2, PIK3R3, PIK3R4, mTOR, AKT1, AKT2, and AKT3, were positively correlated with YTHDF1 transcripts in HCC (Fig. 5B). This evidence concerns the gene PIK3CB and hepatocellular carcinoma.