PIK3R3 and hepatocellular carcinoma: Additionally, correlation analysis by GEPIA showed that multiple key transcripts in the PI3K/AKT/mTOR signaling pathway, such as PIK3CA, PIK3CB, PIK3R2, PIK3R3, PIK3R4, mTOR, AKT1, AKT2, and AKT3, were positively correlated with YTHDF1 transcripts in HCC (Fig. 5B).