Macrocephaly is a hallmark of PHTS individuals, and ASD in the context of germline PTEN mutation is always accompanied by macrocephaly [28, 40, 41]; therefore, to determine whether a similar overgrowth phenotype exists in PtenY68H/+ mice, we performed a gross examination of PtenY68H/+ brains at P40. The gene discussed is PTEN; the disease is PTEN hamartoma tumor syndrome.