To explore whether the growth inhibition of DLBCL cells induced by matrine was caused by apoptosis, SU-DHL-16 and OCI-LY3 cells were treated with the increasing concentrations of matrine for 48 h, and the occurrence of apoptosis was determined by the annexin V and PI staining (Fig. 2a and b). Here, ANXA5 is linked to diffuse large B-cell lymphoma.