The results clearly showed that the expression of CDK6, not CDK4, inhibited by matrine was significantly rescued by the c-Myc adenovirus infection, not by the Control adenovirus infection, in SU-DHL-16 cells (Fig. 6b, d, e and Supplementary Figure 6), which identified that CDK6 is a bona fide c-Myc target gene in SU-DHL-16 cells. The gene discussed is MYC; the disease is adenoviridae infectious disease.