On the other hand, in our study we found elevated levels of IL-10, an anti-inflammatory cytokine with a major role in mitigating inflammation through the ability to inhibit synthesis of non-specific proinflammatory cytokines such as IL-1, IL-6, TNF [31], In view of its anti-inflammatory properties, the IL-10 elevated levels in our sample may represent a homeostatic response to counteract the effects of other cytokines released during acute COVID-19, reflecting a more intense immunologic response to the virus in patients who develop headache. This evidence concerns the gene IL10 and Headache.