BRAF and cancer: Autophagy is believed to inhibit the occurrence of cancer; however, on the other hand, once the cancer is established, the increase in autophagy flux can also promote cancer development.[6,7] Evidence suggests that autophagy can promote invasion and metastasis in case of SKCM.[8] Xie et al[9] reported that autophagy-related gene-7 promotes SKCM by limiting oxidative stress and overcoming aging and that autophagy inhibition may enhance the anti-tumour activity of BRAF inhibitors, and thus may have therapeutic value.