TP63 and neoplasm: The expression of TP63 was increased in approximately 25% of squamous cell carcinomas in multiple organs, including the lung, head, neck, and oesophagus.[37] A study indicated that p63 is highly expressed in skin basal cell carcinoma.[38] In addition, a high incidence of TP63 gene mutations in SKCM samples (14.7% of the samples) was reported.[39] Matin et al[40] reported that as many as 60% of SKCM p63-positive specimens (63/121) are positively correlated with the poor prognosis of SKCM.