Wei et al showed that lncRNA HCP5 overexpression inhibited the development of skin melanoma through a ceRNA mechanism.[39] Jiang et al reported that lncRNA HCP5 was highly expressed and promoted lung adenocarcinoma metastasis via the has-miR-203/SNAI axis.[40] Yu et al suggested that lncRNA HCP5 was overexpressed in cervical cancer tissues and promoted the development of cervical cancer by regulating MACC1 via suppressing microRNA-15a.[41] Our study also showed that lncRNA HCP5 expression was 4.7-fold higher in HCC tissues than in paired normal tissues. The gene discussed is MACC1; the disease is hepatocellular carcinoma.