CDK4 and hepatocellular carcinoma: Jiang et al. found that hsa-miR-199a-5p might be biomarker in the occurrence of HCC.[47] In hepatitis B virus-associated hepatocellular carcinoma (HCC), the low-level expression of hsa-miR-199a-5p lead to the high-level expression of CDK4 and IGF2 mRNA.[48] Wang et al indicated that hsa-miR-424-5p with high accurate prediction.[49] CHEK1-hsa-mir-497-5p was identified as significant interactions, and hsa-mir-497-5p downregulated in hepatocellular carcinoma and display favorable prognostic roles.[50] Besides, there are many miRNAs were considered to be biomarker in HCC.[51–53]