CHEK1 and hepatocellular carcinoma: Survival analysis results suggest that high expression levels of CCNA2 (HR = 1.7, Logrank p = 0.0037), CHEK1 (HR = 2.1, Logrank p = 3.1e−05), FOXM1 (HR = 1.8, Logrank p = 0.00063) and MCM2 (HR = 1.7, Logrank p = 0.0022) are associated with worse overall survival (OS) in HCC patients (P < .01) (Fig. 6b).