Due to the differences in analytical methods, race and region of gene polymorphism, the relationship between CD44 gene rs13347 polymorphism and breast cancer is controversial.[23] Therefore, this study will explore the relationship between CD44 gene rs13347 polymorphism and breast cancer by systematic review and meta-analysis, and provide evidence-based basis for CD44 gene polymorphism in risk assessment, early detection and prevention of breast cancer. This evidence concerns the gene CD44 and breast cancer.