This highlighted, in the list of 24 genes, the presence of the regulator of CD44 splicing TRA2B, and of the splicing factors TRA2A and PRPF38B, for which variations at the same DMR correlated with the same splicing event in both ALL and DKO cells (Figure 8E–G). The gene discussed is TRA2B; the disease is acute lymphoblastic leukemia.