However, statistically significant differences were observed between the mean Ki-67 scores and molecular subtype (p = 0.001), grade (p = 0.003), pN stage (p = 0.007), axillary lymph node metastasis (p = 0.001), and ER and PR statuses (p <0.001); Table 3. The gene discussed is ESR1; the disease is metastatic malignant neoplasm in the lymph nodes.