In contrast, in a meta-analysis encompassing 17 cancer types and 15,512 cancer patients, tumor-infiltrating FoxP3+ Tregs was associated with poor OS in the majority of solid tumors including gastric cancer [21], and Kim et al. also reported that a high Foxp3+ Tregs/CD4 ratio in tumor was an unfavorable prognostic factor for OS in gastric cancer [23]. Here, CD4 is linked to cancer.