Mean values of BMI Z score (p = 0.05), fat mass (kg) (p = 0.05), % body fat (p = 0.03), WC (p = 0.05), FBG (p = 0.04), TC (p = 0.03), serum TG (p = 0.04), ALT (p = 0.05), AST (p = 0.04), ALK (p = 0.003), fasting insulin (p = 0.02) and HOMA-IR (p = 0.01) were significantly increased in severe OSA as compared to mild and moderate OSA (Table 5). This evidence concerns the gene INS and obstructive sleep apnea syndrome.