Regardless, there is ample evidence to show that inflammatory markers [interleukin (IL) 6, IL-8, IL-10, IL-17, IL-18, IL-23, macrophage migration inhibitory factor (MIF), high sensitive C-reactive protein (Hs CRP), tumor necrosis factor-alpha (TNF-α), plasminogen activator inhibitor-1 (PAI-1), and leptin] have been shown to be increased in obese pediatric and adult subjects with OSA [7–12]. The gene discussed is TNF; the disease is obstructive sleep apnea syndrome.