Inflammatory markers showed significantly height levels of IL-6 (p = 0.05), IL-8 (p = 0.03), IL-17 (p = 0.02), IL-18 (p = 0.002), MIF (p = 0.02), Hs-CRP (p<0.0001), TNF-α (p = 0.02), PAI-1 (p = 0.001) and leptin (p<0.0001) in subjects with OSA as compared to healthy controls. This evidence concerns the gene LEP and obstructive sleep apnea syndrome.