Our findings point to clinical characteristics that differentiated between patients with and without mucus hypersecretion, mainly that hypersecretors were older, had severer asthma, greater bronchial obstruction and poorer asthma control, had lower peripheral blood albumin and lower IgE levels, had lower induced sputum lymphocyte levels, were less likely to have prick test-positive asthma and, finally, needed more short-term oral glucocorticoid treatments in the previous year. Here, IGHE is linked to asthma.