One SNP-SNP interaction model demonstrated a significant LRT p-value for T2D when adjusting for the number of tests: rs117537110 (alpha: 0.35; MAF: 0.45; intron, protein phosphatase 1 regulatory subunit 18 (PPP1R18))–rs4149477 (alpha: -0.055; MAF: 0.48; intron, tyrosylprotein sulfotransferase 2 (TPST2)) using the recessive encoding (Bonferroni adjusted LRT p: 0.00051; 5,671 SNP-SNP models tested; r2: 0.00015) (Fig 10 and Sheets A-E in S6 Table). Here, TPST2 is linked to type 2 diabetes mellitus.