One SNP-SNP model met a corrected significance threshold for resistant hypertension using the dominant encoding: rs3801888 (alpha: 0.028; MAF: 0.28) in sorting nexin 10 (SNX10) and rs2858808 (alpha: -1.39; MAF: 0.28) (Bonferroni adjusted LRT p: 0.047; 10,296 SNP-SNP models tested; r2: 0.00037) (Fig 12 and Sheets A-E in S9 Table). Here, SNX10 is linked to hypertensive disorder.