SCN1A haploinsufficiency is the major cause of Dravet syndrome; therefore, mice with heterozygous deletion of Scn1a were developed to model Dravet syndrome (Miller et al. 2014; Ogiwara et al. 2007; Yu et al. 2006). This evidence concerns the gene SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.