SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Scn1a+/− mice recapitulate several core features of Dravet syndrome, including spontaneous seizures, elevated risk of sudden death, and neurobehavioral and cognitive deficits (Han et al. 2012; Hawkins et al. 2017a; Ito et al. 2013; Kalume et al. 2013; Miller et al. 2014; Ogiwara et al. 2013).