While the mechanism of the role of IFN-γ in autoimmunity is not entirely clear, in lupus, LN IFN-γ expression has been linked to the generation of T follicular helper cells cells, GC formation, and the production of autoantibodies and hypergammaglobulinemia (Lee et al., 2012). The gene discussed is IFNG; the disease is systemic lupus erythematosus.