In CRPC, PCa cells evolve resistance to androgen-targetingtherapies by restoring AR signaling through diverse mechanisms, andthe majority of patients present with bone metastases with increasedrisk of morbidity and mortality due to alterations in skeletal integrity.4 Mapping critical pathways involved in establishingCRPC may enable identification of novel therapeutic targets whichcan ultimately reduce disease recurrence.5 Here, AR is linked to posterior cortical atrophy.