KLK14 and posterior cortical atrophy: Interestingly, both KLK2and KLK14 demonstrated dual specificity in certain subpockets, suggestinga role for these subsites in tuning substrate profiles.61 We note that while the present set of probeshas been optimized for PCa, each tissue type expresses a differentset of secreted proteases, and thus the specificity sequence requiredto obtain probe selectivity may depend on the physiological context.