AR and posterior cortical atrophy: As noted above, KLKs2, 3, and 14 have been proposed to play rolesat different stages of PCa progression including facilitating initialprostate tumor expansion and invasion, and establishment of distantmetastases.8 Given that AR activity iscrucial in the development of CRPC and for continued tumor growth,we next assessed how KLK activity changes in response to specificAR signaling perturbations.