CCN1 and neoplasm: (Table 1) The mean concentration of serum CYR61 in EGJ tumor group (n=152), early-stage EGJ tumor group (n=15) and normal group (n=137) was 258.515 ± 191.736 ng/ml, 225.146 ± 114.316 ng/ml, and 429.115 ± 273.432 ng/ml, respectively (Table 2).