Bai et al. developed a multi-channel setup where human umbilical vein endothelial cells (HUVEC) were co-cultured with hydrogel-embedded tumour aggregates and macrophages.37 The effect of different macrophage subtypes on tumour aggregate dispersion was studied to mimic epithelial–mesenchymal transition (EMT), inducing cancer cell dissociation via CD11b and ICAM-1 interaction. Here, ICAM1 is linked to neoplasm.