IRF8 and melanoma: Mattei et al. developed a microfluidic device to study the role of the IRF-8 transcription factor in cross-talk between murine melanoma and immune cells and the release of soluble factors resulting in immune cell infiltration.36 The device was composed of an enclosed central microfluidic chamber with externally accessible compartments on either side for culturing adherent B16.F10 murine melanoma cells and non-adherent splenocytes from wild type (WT) and IRF-8 KO mice.