MMP9 and schizophrenia: Oxidative stress also induces microglial activation and redox‐sensitive MMP stimulation, especially MMP2 and MMP9, leading to activation of inflammatory signaling pathways, such as NF‐κB and secretion of various cytokines that ultimately opens the BBB to facilitate leukocyte migration across the BBB.[255, 256] In schizophrenia, blocking MMP9 activation by the specific MMP2/9 inhibitor SB‐3CT breaks the interaction between oxidative stress and neuroinflammation, leading to accelerated recovery.[257]