Disrupted BBB‐elicited infiltration of peripheral blood factors, such as albumin, globulin, fibrinogen, may make a critical contribution.[76]For example, in AD, leaky BBB increased the influx of albumin and immunoglobulins, contributing to the formation and progress of disease by concentrating in areas of amyloid‐positive vessels and plagues.[76] Prothrombin and thrombin were also found to be increased in senile plaques, leading to pro‐inflammatory response and neuronal cell death. The gene discussed is ALB; the disease is Senile plaques.