ABCC1 and Alzheimer disease: Deficiency of ABCC1 also significantly increased Aβ deposition in the brain without affecting the production of Aβ, suggesting its involvement in the efflux of Aβ from the brain.[105] Activation of ABCC1 by thiethylperazine, a drug used in the clinic to relieve nausea and vomiting, substantially reversed the cerebral accumulation of Aβ in a mouse model of AD with ABCC1 expression.