RTN4 and brain ischemia: As an example, antibodies against Nogo‐A, a neurite outgrowth inhibitor and an angiogenesis inhibitor in the brain,[245] improve vascular sprouting and reduces neurological deficits after cerebral ischemia in mice.[246] These findings were reproduced in a clinical setting where anti–Nogo‐A antibodies were administered intrathecally for spinal cord injury.[246]