Angiopep‐2/LRP1 is attracting considerable interest in brain glioblastoma treatment since LRP1 is highly expressed in both brain endothelial cells, tumor cells of glioblastomas, and brain metastases of lung and skin cancers.[189] Therapeutics targeting LRP1 can be guided not just through the BBB but also to tumor cells in the brain.[203]. Here, LRP1 is linked to skin neoplasm.