Drugs that selectively inhibit NOX4 (GKT136901) and NOX5(ML090) reduced BBB permeability, resulting in a significant reduction of infarct volume and direct neuroprotection when given immediately before or at the time of reoxygenation in a mouse model of cerebral ischemia‐reperfusion.[253, 254]. The gene discussed is NOX4; the disease is brain ischemia.