MFSD2A and cancer: Further studies show that lipids transported by mfsd2a create a unique lipid composition to specifically inhibit, caveolae‐mediated transcytosis, to maintain BBB integrity.[15] In metastatic brain tumor, cancer cells break down the BBB through inhibition of mfsd2a expression, leading to enhanced transcytosis and alteration of lipid metabolism that facilitating metastasis.[130] Therefore, both the lipid composition of brain endothelial cells and Msfd2a may serve as targets to modulate caveolae‐dependent transcytosis in the BBB for therapeutic purposes.