Hypoxia‐activated transcription factors, such as the transcription factor activator protein 1 (AP‐1), nuclear factor E2‐related factor 2 (NRF2), and hypoxia inducible factor 1 (HIF‐1), decrease the therapeutic effects of PDT, and may even promote the tumor invasion and metastasis.[10] Some tumor cells increase their tolerance to high oxidative stress by upregulating the expression of glutathione (GSH) to neutralize ROS.[11] Therefore, an efficient strategy to overcome the limitations of singular PSs is urgently needed for tumor therapy. The gene discussed is HIF1A; the disease is neoplasm.